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This rebound occurs because semaglutide masks underlying hunger signals and metabolic patterns rather than permanently rewiring them, meaning your body's natural appetite-regulation pathways remain unchanged once the drug leaves your system
Monthly weight loss of 3-5 pounds is typical
Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion
10.1016/j.atherosclerosis.2013.08.033 27
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